How can you get unstuck? First we have to understand metabolic flexibility vs. metabolic inflexibility.
Metabolic flexibility is your body’s capacity to adapt to different fuels. Only a very few people have metabolic flexibility and are able to easily go back and forth between high and low carb.
Metabolic inflexibility makes switching from a high carb diet to a low carb diet challenging. The switching back and forth between high carb and low carb diets causes your metabolism to slow down.
Anyone with metabolic inflexibility and will need to try a different approach. You will have to consistently keep insulin levels down, which means no cheat meals or snacks. If you cannot be consistent you actually slow your metabolism. It will take time to adapt to keto.
If you or your family and friends have been affected by cancer please read this condensed version of a recent interview with Dr. Seyfried.
Thomas Seyfried, Ph.D., is a professor of biology at Boston College and a leading expert and researcher in the field of cancer metabolism and nutritional ketosis. Ketogenic therapy calls for restricting net carbs (carbs less fiber) and limiting protein.
Cancer is a metabolic disease, not a genetic one. The genetic mutations observed in some cancers are a downstream effect of defective energy metabolism in the mitochondria (the energy stations inside your cells). As long as your mitochondria remain healthy and functional, your chances of developing cancer are slim.
The traditionally held dogma (view) is that cancer is a genetic disease. As noted by Seyfried:
“A dogma is considered irrefutable truth… The problem with dogma is that sometimes it blinds you to alternative views and sets up ideologies that are extremely difficult to change.
But evidence is accumulating that the mutations we see that are the prime focus and the basis for the genetic theory are actually downstream effects of this disturbance in the metabolism (processes to maintain life) …”
Seyfried complied of research from independent and well-respected scientists within various disciplines, who conducted valuable experiments to form a strong scientific foundation for the theory that cancer is indeed a metabolic disease, not a genetic one, and that genetic mutations are a downstream effect of defective energy metabolism in the mitochondria.
Nuclear Transfer Experiments disproved the gene theory. When the nuclei of a cancer cell were transferred into a healthy cytoplasm (material inside the cell membrane), the new cytoplasm did NOT form cancer.
If genetic mutations are not the primary cause of cancer but rather a secondary, downstream effect of dysfunctional cell respiration, why and how do mutations occur? Seyfried explains, “Once the cells’ respiration (intake of oxygen and release of carbon dioxide) is damaged, that damage then leads to a compensatory fermentation (existing without oxygen), which requires the upregulation (increasing the response) of oncogenes (cancer genes).
Damaged respiration also produces large amounts of reactive oxygen species (ROS) and secondary free radicals that damage DNA proteins and lipids (fats inside your cellular membranes). The ROS also cause mutations in the nuclear genome. So the mutations are the result of defective respiration and subsequent exaggerated ROS production.
Dr. Seyfried says, “Those nuclear transfer experiments were always present in the literature. They were considered anomalies.
It was just interpreting a series of experiments in light of the origin of the disease, and then asking what conclusion would these experiments support. Would it support the nuclear genetic theory of cancer, or would it support the mitochondrial metabolic theory of cancer? In each of these cases, the results more strongly supported the metabolic theory of cancer than the nuclear genetic theory.
Why the War on Cancer Has Not Yet Been Won? The cancer industry is focusing on the downstream effects of the problem. Dr. Seyfried says, “Even though you may get success for a few months, or even a year in some people, the majority of people will not respond effectively to these kinds of therapies.”
If defective mitochondria are responsible for the origin of cancer, and defective energy metabolism is responsible for the majority of the characteristics of the disease, then how do you treat the disease?
The answer is be an efficient fat burner. Fat-derived ketone bodies, through a process, reduce the production of ROS. Hence, ketone bodies are considered a more “clean” fuel. Today, most people are burning glucose as their primary fuel, thanks to an overabundance of sugar and processed grains in the diet and a deficiency in healthy fats.
If you have less ROS being generated in the mitochondria, you end up with less mitochondrial damage and less DNA damage. Switching to ketones to fuel your body is the key component of cancer treatment.
“One of the things that trigger cancer is inflammation. … Chronic high levels of blood sugar create inflammation. … Glucose itself is not carcinogenic, but elevated dysregulated (poorly controlled) glucose metabolism can lead to inflammation, and can cause a number of other disturbances in the overall metabolism of the body,” Seyfried says.
Do Not Confuse Nutritional Ketosis With Ketoacidosis. These are two entirely different states.
As noted by Seyfried, “Mitochondria actually get very healthy when ketones are metabolized as opposed to some of the other fuels, especially glucose.”
What about preventing disease with antioxidants? If you suppress reactive oxygen species (ROS) indiscriminately, you’ll create biological dysfunction. When your body is burning ketones as its primary fuel, you have neither too much nor too little ROS.
It is far more effective to address the ROS generation at its source, which is the fuel your body is primarily burning for energy. Change the fuel, from sugar to fat to generate fewer ROS.
Ketones Prevent Dysregulated ROS Production, Thereby Reducing Your Risk for Cancer: “There’s no question about that. It’s what we call a homeostatic state (the cell’s ability to maintain internal stability),” Seyfried notes. “Ketones prevent dysregulated ROS production… You’re allowing your body to remain healthier for a longer period of time. That’s basically what we’re doing here … Cancer is accelerated entropy, a total disorganization of the homeostatic parameters within cells and outside the cells in the morphogenetic field and in the entire body itself.
When you view cancer as a metabolic disease, as explained by Seyfried, you treat it this by targeting the fuels the cancer cells are using, primarily glucose and glutamine.
According to Dr. Seyfried, if you prevent damage to your mitochondria then the probability of getting cancer is reduced to a least 80%.
Prevent cancer and most of the major diseases by eating less carbs and protein and moving more.
Cancer cells can use glutamine for energy and growth as well. The combination of both glucose and glutamine (the common amino acid in proteins) creates a really “supercharged system,”Seyfried notes.
For more information please read my Blog post, How Do I Do the Ketogentic diet?
If you really want to dig deep into the details of therapeutic ketosis, read Seyfried’s book, “Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer.” If you want to start with a shorter treatise, you can read his paper, “Cancer as a Metabolic Disease: Implications for Novel Therapeutics,” published in the journal Carcinogenesis in 2014,4 or his 2015 paper in the journal Frontiers, titled “Cancer as a Mitochondrial Metabolic
Too many people have died and continue to die needlessly. It’s time to get back on the right track. The information about how to prevent cancer and other chronic illness already exists. It’s just a matter of applying it.
I invite you to Follow my Blog, Facebook or be added to my email distribution list. My focus is to maximize my physical performance and mental clarity, body composition, and most importantly overall health with a wholesome diet and exercise.
I will bring you compelling articles on Ketogenic and GAPS diets, the Super Slow High-Intensity Exercise Program and supplements.
To follow my Blog, please click the Follow button to receive an email when the next posting is available. Hint: You may have to click the Accept and Close button before follow is available.
I thrive on feedback. Please let me know you are interested in the content by clicking Like, Commenting or sending me a message or email about the Post.
If you wish to contact me by Email, please email email@example.com using this form.
Disclaimer: The content of this email or Post is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.
Growing up I had to work extra hard to get over my mild case of dyslexia. I would read the same few words over and over again and I would not understand what I read. It is a relief to know that my diet may have caused the problem.
Since I read Dr. McBride’s book, I have changed my diet dramatically. My dyslexia has much improved. Now, I enjoy reading and understanding what I am reading. Thank you Dr. McBride.
The following information is from her book: Gut and Psychology Syndrome.
GAPS (Gut Psychology Syndrome) children and adults have digestive problems, sometimes quite severe.
GAPS is a natural treatment for colic, bloating, flatulence, diarrhoea, constipation, feeding difficulties and malnourishment, all to various degrees, are a typical part of autism, schizophrenia and other GAPS conditions.
In the majority of cases digestive problems start at weaning time or times when breast milk gets replaced with formula milk and other foods get introduced. In those cases where an adult did not have a history of gut problems from childhood the digestive problems would start later in life due to some health-damaging event.
The second year of life is the time when many autistic GAPS and non-autistic GAPS children start developing fussy eating habits. Many GAPS children and adults prefer processed carbohydrates to the exclusion of everything else. They will only eat starchy and sweet foods: breakfast cereals, chips, popcorn, cakes, biscuits, sweets, bananas, bread, rice, sweet yoghurts.
There is an established a hypothesis of gut-brain connection. It backed by very serious scientific findings, which Dr. Natasha McBride discusses in her book, Gut and Psychology Syndrome.
There is much less published scientific data on gut problems in ADHD, dyslexia, dyspraxia, asthma, allergy, eczema and other GAPS conditions. However, when it comes to clinical observations almost all children and adults with GAPS have digestive problems to various degrees.
Many patients have typical symptoms of IBS (Irritable Bowel Syndrome): abdominal pain, bloating, stool abnormalities and flatulence. Some may have normal stools, but complain about malnutrition, reflux, “heartburn”, abdominal pains and flatulence.
Disclaimer: The content of this email is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.
If you are interested in following my postings, please click the Follow button to receive an email when the next posting is available.
If you wish to comment or contact me please use this form using my email address, firstname.lastname@example.org. Thank you.
Hint: You may have to click the Accept and Close button before follow is available.