The Adrenal can become burnt out.

If you have too much adrenal function like too much cortisol it’s called Cushing’s.
If you have a deficiency of cortisol and other adrenal hormones, that is called Addison’s.
The two big symptoms of adrenal fatigue are chronic fatigue and chronic inflammation. Cortisol normally is an anti-inflammatory. But if the adrenals are weak or you run out of cortisol or it does not work anymore because of cortisol resistance then you get inflammation.
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