The Ketogenic Diet Starves Cancer Cells.

Dr. Mercola interviews Travis Christofferson, the author of Tripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine’s Most Entrenched Paradigms

Christofferson:  Drugs targeting DNA have been very, very disappointing. We’ve been told that these targeted therapies were going to result in cures. It’s clear that’s not the case because of the data from the Cancer Genome Atlas project. There’s just too much random diversity within the genes. It’s hard enough to find a target from one patient to the next and if you do there’s another phenomenon called intra heterogeneity, which is the difference in mutations from cell to cell within the same tumor.

James Watson Nobel, who won the Nobel Prize in 1954 for discovering the structure of DNA, noticed this and said; I am no longer giving money to the Cancer Genome Atlas project. If we’re ever going to cure cancer we’re clearly going to have to go back to the days of Warburg and focus on the metabolism.

Mercola: Warburg was the first person who noted that there’s a difference in the metabolism. Cancer cells are anaerobically metabolizing glucose (without oxygen) inefficiently and they have this relative primitive form of energy generation and it’s inefficient.

So the question becomes what caused them to revert to this? Peter Peterson out of Hopkins took it to the next step, he actually determined that there is a radically reduced number of mitochondria. There are typically several thousand in each cell comprising about a third to 50% of the volume of the inside of your cell. These generate the energies of our cells.

If you’ve got a radical reduction of those and if the ones that are left are relatively dysfunctional, not even working if they work in at all, then you’ve got a problem.  So these cancer cells don’t have a choice, they have to revert to anaerobic metabolism.

Healthy mitochondria send signals, (epigenetic communication) between its cell and the nucleus and this epigenetic signalling from the mitochondria is actually what’s responsible for initiating a significant percentage of the genetic damage that has been identified so well through the DNA sequencing project, which the majority of the scientists have been focused on currently. 

If we’re ever going to cure cancer we have to focus on the metabolism.

Christofferson:  The mitochondrial damage is irrefutable. We look at cancer cells and the number of mitochondria are vastly reduced. When you isolate and look at the mitochondria you look at them, they’re messed up. There are protein problems; there are lipid problems, and all kinds of structural abnormalities. The question is: “Why has the cancer reverted to anaerobic energy generation?” Nobody really tied that to the terrible structure of the mitochondria. They didn’t have the tools to see the mitochondria and now we do.

Tom Seyfried, the leading edge cancer scientist, has done such a great job of piecing together the events once mitochondrial are damaged.  This relationship between mitochondria and the nucleus is so important. They constantly crosstalk and mitochondrial health is correlated to the health of the entire organism, you.

The dominant theory of aging explains that you age because your mitochondria age,they take the brunt of metabolism. When you generate energy you are whipping around free radicals and they’re constantly under stress so they get banged up and beat up and you look at the antioxidants within mitochondria they have declined by about 50% with advanced age.

Mercola: It is important to note, is when they burn fuel they generate these reactive oxygen systems (ROS). But the question is what you fuel are they’re burning?

 They are burning glucose (carbohydrates). They are burning dirty fuel generating tons of reactive oxygen species as opposed to burning ketones or fats.

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Christofferson:  As a fuel ketones are incredible, they burned clean with much less ROS or free radical generation but the clincher with this theory is that once there’s enough mitochondrial damage there is a retrograde response or an epigenetic signal to the nucleus and once this happens then you start to see the accumulation of mutations.

So the whole crux of this theory is which is first? The argument is that the metabolic theory is this mitochondrial damage is how first and then you see the mutations.The mutations appeared as the causebut in fact they are a downstream signalfrom the from the true cause. Researchers were led sort of down this wild-goose chase trying to find what these mutations were and why they were important. So now that we know this we can go back to the mitochondria and ask how do restore our cell and how do we keep them healthy?

The dietary therapy, what Tom Seyfried calls a restricted Ketogenic diet, is the foundation of this therapeutic approach because it does incredible things to the body where it differentiates between cancer cells and normal cells. When you switch from glucose metabolism to ketone metabolism you put energetic pressure on the cancer cells because they have to burn ketones in mitochondria, which is something they don’t have much of.

So we’ve noticed that once you put people in this dietary state everything becomes more effective even traditional chemotherapy even radiation and at the same time you’re mitigating side-effects because healthy tissues are able to withstand the sort of toxic payload from traditional chemotherapy. The exciting thing is when you add on these other metabolic therapies that are synergistic and their mechanisms overlap. Exogenous ketones are exciting.  How far can we take that metabolic state to this tipping point where cancer cells growth is stopped but they begin to die.

We can bring blood glucose levels down way farther than most people think safely. You add gluconeogenesis inhibitors that’s one of the main culprits you have to contend with as far as keeping blood glucose down, you add exogenously tones and people are put in this different metabolic state.

They’re shifting away from carbohydrate metabolism and then add on pulses of pressure: 3bromopyruvate(3-BrPA) and dichloroacetate (DCA) are inhibitors and Metformin. They are very non-toxic that overlap and mechanism.

This foundational shift to a ketone-based metabolism followed by these pulses of pressure appears to be the best avenue to a cure.  

Ketone bodies are not just a fuel they’re signalling molecules. Incredibly restorative things happen: you completely rearrange the architecture of your DNA; you start expressing new genes; you drop down the inflammatory genes and boost all these restorative genes. There is mitochondrial biogenesis. Look at all the diseases that spin out of this metabolic dysfunction from not entering the state of ketosis periodically – neurodegenerative diseases such as Alzheimer’s, Parkinson’s, obesity, diabetes, heart failure, heart disease, arthritis, cancer, and the list goes on.

A shift in macromolecular consumption from carbohydrates to fats can stop diseases. It goes back to Dr. Veech who was the lineage of Otto Warburg. He got his PhD in under Hans Krebs. He’s done a lot of this ketone body research along with Cahill and he said in late 70s or 80s that so many disease states spin out of a function of mitochondrial decay and the ketone bodies can potentially mitigate this process. Now we have exotic ketones that maybe help people that aren’t able to do the dietary restrictions.

The ketogenic diet really is just the maintenance of the fasting state nutritionally. Periodic fasting can be difficult because you transition through this induction phase. Your body is tooled up to burn carbohydrates, so when you fast it has to retool and during that process you burn muscle as a bridge to get you over to fat metabolism.

All evidence points to maybe not a huge increase in lifespan but it definitely a huge increase in health span. For example, if you were predisposed to getting type 2 diabetes in midlife, if you were in ketogenic state you may never get it. So if you want to live well for a long time that is were the benefit will be.

Here is the link to Travis Christofferson’s book Tripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine’s Most Entrenched Paradigms  https://www.amazon.ca/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292

This Post has the highlights of the interview with Dr. Mercola & Travis Christofferson on the Metabolic Theory of Cancer https://www.youtube.com/watch?v=WvNaO0Poeqs

I invite you to Follow my Blog, Facebook or be added to my email distribution list. My focus is to maximize my physical performance and mental clarity, body composition, and most importantly overall health with a wholesome diet and exercise.

 I will bring you compelling articles on Ketogenic and GAPS diets, the Super Slow High-Intensity Exercise Program and supplements.

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May you Live Long Healthy.

Yours truly,

Lydia Polstra

Email: lpolstra@bell.net

Facebook: https://www.facebook.com/2healthyhabits/

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Disclaimer: The content of this email or Post is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.

Key Dietary Strategies to Protect Yourself from Alzheimer’s

Highlights:

  • Diets high in carbohydrates, and diets low in healthy fats, lead to Alzheimer’s disease
  • Diets high in carbohydrates are associated with an 89 % increased risk for dementia. High-fat diets are associated with a 44 % reduced risk
  • Alzheimer’s is directly related to chronically elevated blood sugar levels
  • Diabetes doubles your risk for Alzheimer’s disease
  • You can regenerate cells in your brain’s memory center through a process called neurogenesis.
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Saturated Fats Are a Critical Part of a Heart- and Brain-Healthy Diet. Saturated fat is needed to have good cholesterol in your body.

Dr. Perlmutter cites a study published in the Archives of Internal Medicine, which found that women who are given cholesterol-lowering statin medication have a 44 % increased risk for becoming a type 2 diabetic.Diabetes, in turn, doubles your risk for Alzheimer’s disease.

Alzheimer’s Is Directly Related to Elevated Blood Sugar Levels.     A study published in the New England Journal of Medicine in August 2013 demonstrates that even mild elevation of blood sugar – a level of around 105 or 110 mg/dl – was associated with an elevated risk for becoming demented.

Dr. Perlmutter believes the ideal fasting blood sugar level is around 70-85. People who are keto-adapted (eating low-carb, high-fat) are burning fat and they can get by with much lower blood sugar.

Your brain does not need sugar. The brain loves to burn fat, specifically ketones, which your body produces by metabolizing your fat.

Eat the Right Types of Fat:             Healthy fats include Avocados, Butter made from raw, grass-fed organic milk, Raw dairy, Organic pastured egg yolks, Coconuts and coconut oil, Unheated organic nut oils, Raw nuts, such as pecans and macadamia, which are low in protein and high in healthy fats, and Grass-fed meats. Avoid all trans fats or hydrogenated fats i.e. margarine, vegetable oils, and butter-like spreads.

Our ancestral diet was very high in saturated fats and virtually void of non-vegetable carbohydrates. Our bodies were not designed to eat carbs are refined and highly processed and foods that are genetically engineered grains and sugar (GMO sugar beets and corn). 

This underpins almost every health malady that we are trying to deal with today.

Exercise reduces free radical production and inflammation,both of which are drivers for chronic disease. Exercise has been shown to turn on a brain growth hormone called BDNF, (brain-derived neurotrophic factor). BDNF codes for your brain’s ability to both repair itself and grow new brain cells.

Dr. Perlmutter recommends high-intensity interval training (HIIT), which provides you with the equivalent of two hours of conventional aerobic exercise in just 20 minutes.

Learn more at 15 minutes of resistance weight training is all the exercise I need for the week to build muscle.

https://2healthyhabits.wordpress.com/2018/05/25/15-minutes-of-resistance-weight-training-is-all-the-exercise-i-need-for-the-week-to-build-muscle/

Dr. Perlmutter’s Grain Brain program includes other recommendations, not limited to:

  • Turmeric, for its anti-inflammatory potential and ability to activate BDNF for brain health.
  • An optimal vitamin D level of around 70-90 nanograms per milliliter (ng/ml) year-round.
  • Optimizing your gut health by reseeding your gut with beneficial bacteria (probiotics).
  • Avoid antibiotics and eating CAFO meats (concentrated animal feeding operations)which provide you with traces of antibiotics in each bite. These antibiotics kill beneficial bacteria.
  • Measuring your gluten sensitivity with a Cyrex [Array 3] test.Dr. Fasano discovered that gluten can also make your blood-brain barrier leaky.

A high-fat, low-carb ketogenic diet is not just for the treatment of Alzheimer’s and other forms of dementia. It’s the right diet for ALL brain-related disorders. 

Choose above-ground vegetables which, include kale, chard, collards, broccoli, and spinach. These also contain plenty of healthy fiber – you really do not need grains.

Choose grass-fed products – wild fish, pasture-raised chicken, and farm-raised or pasture-raised eggs.

This Post has been condensed from Key Dietary Strategies to Protect Yourself from Alzheimer’s https://articles.mercola.com/sites/articles/archive/2014/04/27/diet-alzheimers-disease.aspx

 I invite you to Follow my Blog, Facebook or be added to my email distribution list. My focus is to maximize my physical performance and mental clarity, body composition, and most importantly overall health with a wholesome diet and exercise.

 I will bring you compelling articles on Ketogenic and GAPS diets, the Super Slow High-Intensity Exercise Program and supplements.

To follow my Blog, please click the Follow button to receive an email when the next posting is available. Hint: You may have to click the Accept and Close button before follow is available.

I thrive on feedback. Please let me know you are interested in the content by clicking Like, Commenting or sending me a message or email about the Post.

If you wish to contact me by Email, please email lpolstra@bell.net using this form.

May you Live Long Healthy.

Yours truly,

Lydia Polstra

416-428-5285

Email: lpolstra@bell.net

Facebook: https://www.facebook.com/2healthyhabits/

Blog: https://2healthyhabits.wordpress.com

Disclaimer: The content of this email or Post is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.

My mission is to help people like you get well and stay well. – Dr. Raymond Francis

Raymond Francis, D.Sc., M.Sc., RNC has been called a “brilliant advanced thinker” and has been cited as “one of the few scientists who has achieved a breakthrough understanding of health and disease.”blog jan. 11 hoax image

This Post is Transcript from Dr. Raymond Francis’s 4.47 minute video Processed Foods.

My mission is to help people like you get well and stay well.

Most nutrition experts agree, don’t eat processed foodsand here’s a problem. There is a lot of confusion about what is a processed food, so let me try and add some clarity.

Virtually ALL the packaged goods you buy in a supermarket are processed foods. They’re unhealthy. Processing is anything you do to a raw agricultural commodity after it’s been harvested.Now some processing is benign you know chopping up an apple cutting an apple or chopping some onions.  This is this is minor stuff it’s processing but it’s minimally processed. Minimally processed foods have been used safely since antiquity. They fermented foods, they sun-dried foods.

It’s the modern highly processed foods that are killing us.For example, processing whole wheat into white flour looses the fiber, the essential fatty acids and about 80 percent of the vitamins and minerals.

The average American is eating well over a hundred pounds of this junk every year. Bad enough by itself white flour is then used to create baked goods. These baked goods contain toxins like azodicarbonamide, which is a dough conditioner, caramel coloring, monoglycerides and diglycerides, which are emulsifiers, salt, potassium bromate, which is a carcinogen but it helps the dough to rise higher and gives the bread a nice white color, sugar, processed fats and oils, artificial colors flavors, preservatives. It kind of be nuts to eat this stuff and we’re consuming it by the ton.

Remember, there are only two causes of diseases – deficiency and toxicity.

Modern processing loses nutrients and adds toxins and this is why processed foods cause disease. Beware of foods that come in cans and jars and packages. These include all your baked goods and your pasteurized milk and your breakfast cereals and canned goods and frozen foods and prepared meals. We’ve been taught that frozen food is as good as fresh food. That isn’t true. Frozen foods are not as good as fresh foods. Vegetables are blanched prior to freezing. This results in losing folate, B vitamins, about 25% of vitamin C.

However it’s about choices and in the absence of fresh foods, frozen vegetables may be your best choice. So read labels carefully. The key is to minimize and avoid the worst choices. Especially stay away from those with a LONG list of ingredients. Stay away from these prepackaged things: prepackaged meals and canned foods and baked goods and deli meats and breakfast cereals and supermarket oils and anything that contains flavor enhancers and salt and emulsifiers and stabilizers from sweeteners and thickeners and added fats and oils and processing aids. Wow!

Choose food items with the least amount of stuff in it, no artificial colors, no artificial preservatives, no added sugars, no sodium, no added fats and oils. That’s the best you can do.

But the healthiest choice of all is always freshly harvested, organically produced plant-based foods.  So as much as possible eat vegetables raw. Eat lots of fresh salads dressed with high-quality olive oil or flaxseed oil. In addition high-quality supplements are essential. To learn more about how to get well and stay well read my book The Great American Health Hoax.

My personal journey to improved health was heavily influenced by Dr. Raymond Francis’s book, Never be Sick Again. The rest of his books, Never Be Fat Again, Never Feel Old Again, Never Fear Cancer Again,  also have tips on how to improve your health.  I highly recommend his books.

Amazon sells his books https://www.amazon.ca/s/ref=nb_sb_ss_i_1_7?url=search-alias%3Dstripbooks&field-keywords=raymond+francis&sprefix=raymond%2Cstripbooks%2C173&crid=30D6JYORI5SVY

Please more about Raymond Francis at https://www.facebook.com/RaymondFrancisAuthor/

 I invite you to Follow my Blog, Facebook or be added to my email distribution list. My focus is to maximize my physical performance and mental clarity, body composition, and most importantly overall health with a wholesome diet and exercise.

I will bring you compelling articles on Ketogenic and GAPS diets, the Super Slow High-Intensity Exercise Program and supplements.

To follow my Blog, please click the Follow button to receive an email when the next posting is available. Hint: You may have to click the Accept and Close button before follow is available.

I thrive on feedback. Please let me know you are interested in the content by clicking Like, Commenting or or sending me a message or email.

If you wish to contact me by Email, please email lpolstra@bell.net using this form.

May you Live Long Healthy.

Yours truly,

Lydia Polstra

416-428-5285

Email: lpolstra@bell.net

Facebook: https://www.facebook.com/2healthyhabits/

Blog: https://2healthyhabits.wordpress.com

Disclaimer: The content of this email or Post is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.