What are the benefits of intermittent fasting on your immune system?

The benefits of fasting are amazing – especially if you can do a 72-hour fast. Most people will need to build up to a fast this long by starting with a 48-hour fast. It’s a good idea to do a 48 or 72-hour fast periodically – maybe once every month or two.

The benefits of fasting on the immune system have to do with growing a new immune system.

Benefits:

Continue reading “What are the benefits of intermittent fasting on your immune system?”

Bullet Proofing The Immune System.

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Your immune system protects you against disease.

The main cells in your immune system are the white blood cells. Your immune system is also made up of friendly bacteria known collectively is called the microbiome or flora. Those microbes help you in many ways from absorption of nutrients, to recycling of bile, to immune defenses. They’ll make it so there’s just not enough space or food for a pathogen to live.

Our white blood cells actually make enzymes to help break down and kill microbes and pathogens. Our white blood cells generate mucus and inflammation and these pathogens get caught up in this mucus web, it’s like quicksand.

Our immune system has a memory. When there’s a microbe that actually comes back into our body, the immune system actually tags it because it as a memory of that and it can destroy it.  So it actually learns over time by being exposed to pathogens. That’s called building up your immune system and this is why as a child it’s not very healthy to keep a child just so utterly sterile that they’re never exposed or they’re never sick. It’s a natural part of building the immune system.

Continue reading “Bullet Proofing The Immune System.”

Are You Susceptible To The Corona Virus?

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In this video, Eric Berg, DC, a chiropractor and health educator,talks about susceptibility to the coronavirus and other viruses in general.  https://www.facebook.com/drericberg/videos/233619684694276/

Here are the highlights.

The purpose of the virus is to be delivered to the host, your cells, so it can be copied and continue. The corona virus has an affinity for the lungs.

The virus goes through five stages: 

Continue reading “Are You Susceptible To The Corona Virus?”

How Fasting Benefits Your Body.

This is an overview of how powerful fasting is for various parts of your body. 

BRAIN- Fasting stimulates BDNF (brain-derived neurotrophic factor). It is like Miracle Grow for the brain. BDNF helps repair and regenerate neurons. Fasting also helps with stress resistance, neurogenesis (nerve support cells), mitochondrial production, and reducing inflammation. It helps if there is damage as in Alzheimer’s, or Parkinson’s.

BRAIN FUNCTION- Fasting helps improve the number of mitochondria, the energy factories in all body cells including your brain. You will have better memory. You will be able to focus.  You will have better cognitive function.  

INFLAMMATION- Fasting decreases inflammation, which is deadly inflammation on the different parts of the body. There is nothing more powerful than fasting to handle inflammation.

Continue reading “How Fasting Benefits Your Body.”

Calories Versus Appetite On Keto.

Are confused about the Ketogenic (Keto) Diet and Intermittent Fasting (IF) concerning calories, and the concept of not eating unless you’re hungry.

The mainstream recommendation for calories per day is: 

Female — 2000 

Male — 2500 

But, of course, the mainstream recommendation doesn’t take into account that you’re doing keto and intermittent fasting. 

When you’re doing keto and intermittent fasting, you’re switching your fuel source to your own fat calories. When counting calories it is not just about the dietary calories you’re consuming, you need to include the calories that are on your body as stored fat. A non-fat person has over a hundred thousand calories of fat an obese person has 200,000 or more calories.

Continue reading “Calories Versus Appetite On Keto.”

Improve Your Immune System With Intermittent Fasting

A healthy immune system will protect you from developing illness and being infected by bacteria and viruses.

In this video, Dr. Berg talks about how to supercharge your gut microbes with intermittent fasting.

The health benefits are the following:

1. Increase resistance to oxidative stress (aging) + xenobiotic stress (exposure to chemicals)

2. Increase diversity of microbes, which important to your gut health.

3. Increase tolerance to bad bacteria

4. Restores intestinal epithelium (lining of the colon)

5. Microbes live longer

6. Starve off sugar for yeast and candida

Intermittent fasting will kill off the bad population, the pathogenic microbes, and you help the good population. These microbes do a lot for you. They help recycle and increase your bile acids, which help you digest fats and extract fat-soluble vitamins and omega-3 fats.

Continue reading “Improve Your Immune System With Intermittent Fasting”

Your Immune System is Mostly Gut Bacteria.

Today we will discuss the relationship between your microbiome, (friendly gut bacteria) and your immune system.

In fact 70% of your immune system is this microbiome, your gut bacteria. You have trillions and trillions of microbes living in and around your body that are a constantly exchanging with you. 

You are giving them a place to live and they give you immune protection, they give you nutrients, they help your blood sugars and they give you other things that are beneficial. 

Continue reading “Your Immune System is Mostly Gut Bacteria.”

How Sugar, Specifically High Blood Sugar, Affects Your Immune System.

We are talking about hyperglycaemia. It has a huge effect on suppressing your immune system.

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Hyperglycemia, an excess of glucose in the bloodstream, often associated with diabetes, is one of the big factors involved in the COVID situation, massively increasing your risk for mortality.

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How does high sugar affect your immune system?

Firstly, because high blood sugar inhibits chemotaxis, which is the movement of white blood cells through the body towards where they need to do their work like an infection or a part of the body that’s damaged.  It is the movement of white blood cells that is triggered by certain chemicals in the body.

Secondly, we have impaired phagocytosis. Phagocytosis is the mechanism where certain white blood cells will engulf and eat and kill pathogens: viruses, bacteria, fungus and mold. There are two main phagocytes. The neutrophils, which make up 90% of all the pus in your body after an infection. They’re very short-lived. With high sugar you have less neutrophils.

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The other phagocytes are the macrophages. They are the big phagocytes they are there to guard to protect you. They will engulf pathogens and eating them up and put them in these little vesicles and dumping acid in there hydrogen peroxide, the main ingredient in Bleach, and that’s how they kill these microbes.

You have less neutrophils, less macrophages and you have less of their weapons. You take down a big part of the body’s army when you have high blood sugar or when you consume a lot of sugar.

Third, you have inhibited complement cascade. Complement cascade is a series of events that occur that will cause the bacterial membrane to burst. Basically it’s a mechanism to help kill bacteria.

Fourth, when you have high levels of sugar in the blood, you develop acidosis. The body’s pH starts to go down making, it is more acidic and that by itself inhibits immunity.

Fifth, it slows the white blood cells moving through the tissues. These white blood cells have the ability to actually go right through your tissues, right through the lymphatic system, through organs, through blood vessels. All that movement is inhibited.  It is like having your own army and they had to walk through a huge muddy field and they were getting stuck and they couldn’t move that well.  That’s what happens to your immune system.

Sixth, One of the big effects of having high blood sugar is the destruction of the vascular system, especially to the nerves to other parts of the body. With high sugar you’re going to have less oxygen through the body and with that you’re going to have an increase microbes that can live in that environment. They’re called anaerobes. They are pathogens that live in areas that don’t require oxygen such as fungus and candida. This is going to increase the risk for infection, fungal infections, Candida infections, and many other types of pathogens.

Lastly, you’re going to have less of an innate immunity and that’s part of the immune system that is the wall – your the skin and the inner skin and hyperglycemia destroys those barriers so now we don’t have that protection like we did when we were healthy.

If you personally have hyperglycemia and you’re diabetic check out this video Dr. Berg’s Healthy Ketogenic Diet Basics https://www.youtube.com/watch?v=vMZfyEy_jpI

This post has been condensed from Dr. Berg’s video How sugar, specifically high blood sugar, affects your immune System. https://www.youtube.com/watch?v=mqd-MdtES4s

For more information check out Drs. Stephen Phinney and Jeff Volek on the Basic Science of Ketosis and Keto-Adaptation  https://2healthyhabits.wordpress.com/2019/03/15/drs-stephen-phinney-and-jeff-volek-on-the-basic-science-of-ketosis-and-keto-adaptation/

Disclaimer: The content of this email or Post is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.

I invite you to Follow my Blog, Facebook or be added to my email distribution list. My focus is to maximize my physical performance and mental clarity, body composition, and most importantly overall health with a wholesome diet and exercise. 

I will bring you compelling articles on Ketogenic and GAPS diets, the Super Slow High-Intensity Exercise Program and supplements.

To follow my Blog, please click the Follow button to receive an email when the next posting is available. Hint: You may have to click the Accept and Close button before follow is available. 

Please let me know you are interested in the Post by clicking Like, Commenting or sending me a message or email about the Post.

If you wish to contact me by Email, please email lpolstra@bell.net using this form.

May you Live Long Healthy.

Yours truly,

Lydia Polstra

https://2healthyhabits.wordpress.com/

How Can Ketogenesis And Ketones Treat Inflammation?

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Inflammation is a biological mechanism our bodies use to deal with internal and external events, such as combatting infections, repairing tissues or mitigating the immediate consequences of a fractured bone.

However, it often carries a negative connotation since many diseases provoke symptoms through the process of inflammation.

So although it is absolutely necessary for keeping the human body functioning properly, like so many things in biology, too much or too little is the problem. Inflammation can be managed with and without drugs. 

We will focus on ketogenesis and ketones with regards to treating inflammation.

What is ketogenesis?

Ketogenesis is a series of biochemical reactions that builds ketones from parts of other ones (like 2 acetyl-CoA molecules).

How ketone bodies are formed?

The liver is where fat is used as the raw material to produce the ketone D- β –hydroxybutyrate.

Once you’ve produced enough ketones by upregulating** ketogenesis, you eventually move into a metabolic state called ketosis. People are in ketosis when they are on a ketogenic diet or fasting.

** Upregulating: increasing responsiveness by increasing the number of receptors on the cells.

Ketogenesis

Consuming very few calories or carbohydrates releases the main metabolic break that was stopping your body from producing ketones unnecessarily. The decision to make ketones or not happens at the metabolic ‘roundabout’ in our body.

Please see the image of the traffic roundabout.

Blog - 2 Traffic circleThis roundabout is called the Krebs cycle, or the TCA cycle (tricarboxylic acid cycle). The TCA cycle acts more like a traffic circle on a busy highway in which the flow of cars into the circle must be balanced by the flow out.

Keeping with this analogy, ketogenesis results from changes in the balance of cars entering and exiting the roundabout. Specifically, when the ratio of Oxaloacetate to Acetyl-CoA drops below 1, more and more fats get turned into ketones.

How are ketones metabolized?

Your body builds ketones in the liver (ketogenesis), uses them up in other tissues (ketolysis). Ketolysis is the process where ketones are broken down into smaller molecular units that get consumed.

Ketones are fully metabolized by a series of enzymes that break them down into acetyl-CoA molecules, which produce the energy currency of your cells, ATP.

What does ketosis do to the body?

Ketosis is a metabolic state that helps to handle long fasts and carbohydrate restriction. Ketogenesis is an important adaptation our ancestors evolved to help them get through ice ages. Humans developed the ability to store lots of energy as body fat that turned into energy-efficient molecules [6,7].

Please see the image Table 23-5 Available Metabolic Fuels in a Normal-Weight 70 kg Man and in an Obese 140 kg Man at the Beginning of a Fast.

Please notice each of the men would survive without food in this table. [8]

Blog - 3 Table 23-5 Available Metabolic Fuels in a Normal-Weight 70 kg Man and in an Obese 140 kg Man at the Beginning of a Fast.

Ketones are also signaling molecules. They play a role in how the nervous system manages energy use during periods of fasting [9].

Ketones also affect inflammatory processes and structures. One structure is the NLRP3 inflammasome.

What’s the NLRP3 inflammasome?

It is part of theinnate immune system, the defence system we have to react quickly and non-specifically to biological threats, such as a sudden infection from a wound.

It mediates the release of cytokines by the NLRP3 inflammasome. It can also give the go-ahead for cells to activate caspase-1, a major switch used by the cell to decide whether or not to commit suicide.

The NLRP3 inflammasome senses threats, which may be toxins such as too much glucose. It may be mitigated somewhat by stimulating ketogenesis to help dampen the activity of this inflammasome. Ketogenesis can be engaged by eating a high-fat diet low in carbohydrates and by fasting (intermittently) or for longer periods of time.

How does ketogenesis or ketones modulate the NLRP3 inflammasome?

The ketone body β-hydroxybutyrate, (BhB) sticks to the NLRP3 inflammasome and stops it from firing the cytokines that are causing inflammation. It also stops the inflammasome from activating the caspase-1 switch [11].

What diseases or conditions could benefit from dampening NLRP3-mediated inflammation?

Obesity – The fat tissue of people with severe obesity is highly inflamed due mainly to the activity of the NLRP3 inflammasome [13].

The figure below depicts imbalances in the elements listed on the left-hand side leading to insulin resistance via NLRP3 inflammasome activation, and resulting in the diseases and symptoms listed on the right-hand side [15].

Please see the image of the Nlrp3 Inflammasome and Insulin Balance below.Blog - 4 InsulinRheumatoid arthritis – Rheumatoid arthritis is a condition where joints like the knees and wrists are swollen, stiff and painful. It has a major inflammatory component to it. The cytokine bullet fired by the NLRP3 inflammasome, destroys cartilage in rheumatoid arthritis.

Epilepsy (or other CNS disorders)– Epilepsy can present in many ways but generally it can be described as a strong sensory disturbance leading to convulsions and loss of consciousness. It is thought to be due to electrical disturbances in the brain since this feature very strongly correlates with seizure activity.

  • There is evidence suggesting that brain cells with dysregulated production of reactive oxygen species (ROS) or inappropriate K+ efflux activate the NLRP3 inflammasome and trigger epilepsy [17].
  • The human brain is particularly well suited to using ketone bodies as a major source of energy, which makes its therapeutic use for epilepsy all the more intriguing.
  • Fasting or a combination of these interventions could be useful to control NLRP3-mediated inflammation

What kind of ketone-based metabolic therapy should I use?

It’s not always clear which aspect of a ketogenic diet used to reverse obesity is actually doing the work. Is it the appetite suppressing effects? Is the lowered inflammation in fat tissue normalizing local insulin signaling? Or is it a combination of both and more? And in epilepsy, is a ketone-based metabolism improving seizure control through normalized ROS signaling? Or is it due to dampened inflammation deriving from NLRP3 inflammasome activity? Whatever the case may be, there are different ketone-based approaches that are available and worth considering.

For a drug-centric approach, exogenous ketones are available, such as ketone esters and ketone salts. One advantage with exogenous ketones is it is easier and quicker to get a desired level of ketones circulating in the bloodstream than it is through dietary manipulation.

Please see my blog, Ketone Supplements: The Pros and Cons https://2healthyhabits.wordpress.com/2019/06/07/ketone-supplements-the-pros-and-cons/

For drug-free approaches, ketogenic diets or some form of fasting can generate levels of ketones that have therapeutic effects on inflammation. Fasting or intermittent-fasting is a time-tested intervention in obesity as well as epilepsy.

It is free and human physiology is well adapted to it. But it cannot be bottled and sold for profit so, it is discouraged by the food industry and medical establishment.

Ketogenic diets are cheaper than medications for epilepsy or immune therapies for rheumatoid arthritis. It is recommended that you consult dietitians or doctors that can help you implement a well-formulated ketogenic diets.

Conclusion

  • Inflammation is a life-maintaining biological process. However, it needs to be kept in check and not activated chronically above a certain level or it can lead to symptoms or disease.
  • It can be controlled with exogenous ketones or by being in ketosis. Their use should preferably be discussed with medical professionals beforehand, especially when suffering from a medical condition and taking medications.

This Post has been condensed from https://breaknutrition.com/how-ketogenesis-and-ketones-treat-inflammation/

Please see the original for the Footnotes and Citations for the scientific studies.

Disclaimer: The content of this email or Post is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.

I invite you to Follow my Blog, Facebook or be added to my email distribution list. My focus is to maximize my physical performance and mental clarity, body composition, and most importantly overall health with a wholesome diet and exercise. 

I will bring you compelling articles on Ketogenic and GAPS diets, the Super Slow High-Intensity Exercise Program and supplements.

To follow my Blog, please click the Follow button to receive an email when the next posting is available. Hint: You may have to click the Accept and Close button before follow is available.

I thrive on feedback. Please let me know that you like the Post by clicking Like, or Commenting on the content.

If you wish to contact me by Email, please email lpolstra@bell.net using this form.

May you Live Long Healthy.

Yours truly,

Lydia Polstra

https://2healthyhabits.wordpress.com

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