Cancer is a metabolic disease, not a genetic one. The genetic mutations are a downstream effect of defective energy metabolism.

If you or your family and friends have been affected by cancer please read this condensed version of a recent interview with Dr. Seyfried.

Thomas Seyfried, Ph.D., is a professor of biology at Boston College and a leading expert and researcher in the field of cancer metabolism and nutritional ketosis. Ketogenic therapy calls for restricting net carbs (carbs less fiber) and limiting protein.

Cancer is a metabolic disease, not a genetic one. The genetic mutations observed in some cancers are a downstream effect of defective energy metabolism in the mitochondria (the energy stations inside your cells).  As long as your mitochondria remain healthy and functional, your chances of developing cancer are slim.

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The traditionally held dogma (view) is that cancer is a genetic disease. As noted by Seyfried:

“A dogma is considered irrefutable truth… The problem with dogma is that sometimes it blinds you to alternative views and sets up ideologies that are extremely difficult to change.

But evidence is accumulating that the mutations we see that are the prime focus and the basis for the genetic theory are actually downstream effects of this disturbance in the metabolism (processes to maintain life) …”

Seyfried complied of research from independent and well-respected scientists within various disciplines, who conducted valuable experiments to form a strong scientific foundation for the theory that cancer is indeed a metabolic disease, not a genetic one, and that genetic mutations are a downstream effect of defective energy metabolism in the mitochondria.

Nuclear Transfer Experiments disproved the gene theory.   When the nuclei of a cancer cell were transferred into a healthy cytoplasm (material inside the cell membrane), the new cytoplasm did NOT form cancer.

If genetic mutations are not the primary cause of cancer but rather a secondary, downstream effect of dysfunctional cell respiration, why and how do mutations occur?  Seyfried explains, “Once the cells’ respiration (intake of oxygen and release of carbon dioxide) is damaged, that damage then leads to a compensatory fermentation (existing without oxygen), which requires the upregulation (increasing the response) of oncogenes (cancer genes).

Damaged respiration also produces large amounts of reactive oxygen species (ROS) and secondary free radicals that damage DNA proteins and lipids (fats inside your cellular membranes). The ROS also cause mutations in the nuclear genome. So the mutations are the result of defective respiration and subsequent exaggerated ROS production.

Dr. Seyfried says,  “Those nuclear transfer experiments were always present in the literature. They were considered anomalies.

It was just interpreting a series of experiments in light of the origin of the disease, and then asking what conclusion would these experiments support. Would it support the nuclear genetic theory of cancer, or would it support the mitochondrial metabolic theory of cancer? In each of these cases, the results more strongly supported the metabolic theory of cancer than the nuclear genetic theory.

Why the War on Cancer Has Not Yet Been Won?      The cancer industry is focusing on the downstream effects of the problem. Dr. Seyfried says, “Even though you may get success for a few months, or even a year in some people, the majority of people will not respond effectively to these kinds of therapies.”

If defective mitochondria are responsible for the origin of cancer, and defective energy metabolism is responsible for the majority of the characteristics of the disease, then how do you treat the disease?

The answer is be an efficient fat burner. Fat-derived ketone bodies, through a process, reduce the production of ROS. Hence, ketone bodies are considered a more “clean” fuel. Today, most people are burning glucose as their primary fuel, thanks to an overabundance of sugar and processed grains in the diet and a deficiency in healthy fats.

If you have less ROS being generated in the mitochondria, you end up with less mitochondrial damage and less DNA damage. Switching to ketones to fuel your body is the key component of cancer treatment.

    “One of the things that trigger cancer is inflammation. … Chronic high levels of blood sugar create inflammation. … Glucose itself is not carcinogenic, but elevated dysregulated (poorly controlled) glucose metabolism can lead to inflammation, and can cause a number of other disturbances in the overall metabolism of the body,” Seyfried says.

Do Not Confuse Nutritional Ketosis With Ketoacidosis. These are two entirely different states.

As noted by Seyfried, “Mitochondria actually get very healthy when ketones are metabolized as opposed to some of the other fuels, especially glucose.”

What about preventing disease with antioxidants?  If you suppress reactive oxygen species (ROS) indiscriminately, you’ll create biological dysfunction. When your body is burning ketones as its primary fuel, you have neither too much nor too little ROS.

It is far more effective to address the ROS generation at its source, which is the fuel your body is primarily burning for energy. Change the fuel, from sugar to fat to generate fewer ROS.

Ketones Prevent Dysregulated ROS Production, Thereby Reducing Your Risk for Cancer:       “There’s no question about that. It’s what we call a homeostatic state (the cell’s ability to maintain internal stability),” Seyfried notes. “Ketones prevent dysregulated ROS production… You’re allowing your body to remain healthier for a longer period of time. That’s basically what we’re doing here … Cancer is accelerated entropy, a total disorganization of the homeostatic parameters within cells and outside the cells in the morphogenetic field and in the entire body itself.

When you view cancer as a metabolic disease, as explained by Seyfried, you treat it this by targeting the fuels the cancer cells are using, primarily glucose and glutamine.

According to Dr. Seyfried, if you prevent damage to your mitochondria then the probability of getting cancer is reduced to a least 80%.

Prevent cancer and most of the major diseases by eating less carbs and protein and moving more.

Cancer cells can use glutamine for energy and growth as well. The combination of both glucose and glutamine (the common amino acid in proteins) creates a really “supercharged system,”Seyfried notes.

For more information please read my Blog post, How Do I Do the Ketogentic diet?

https://2healthyhabits.wordpress.com/2018/04/13/how-do-i-do-the-ketogenic-diet/

Restrict your net carbs (carbs less fiber) below 50 grams per day and your protein to below 1 gram per kilogram of lean body mass.How much protein is outlined in my Blog post https://2healthyhabits.wordpress.com/2018/11/09/how-much-protein-do-you-need-in-nutritional-ketosis/

For the layperson, Dr. Seyfried is a major contributor to the book, Tripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine’s Most Entrenched Paradigms https://www.amazon.ca/Tripping-over-Truth-Overturning-Entrenched/dp/1603587292/ref=pd_lpo_sbs_14_t_0?_encoding=UTF8&psc=1&refRID=VX20GWBM2VV4VYH885FK

If you really want to dig deep into the details of therapeutic ketosis, read Seyfried’s book, “Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer.”  If you want to start with a shorter treatise, you can read his paper, “Cancer as a Metabolic Disease: Implications for Novel Therapeutics,” published in the journal Carcinogenesis in 2014,4 or his 2015 paper in the journal Frontiers, titled “Cancer as a Mitochondrial Metabolic

Too many people have died and continue to die needlessly. It’s time to get back on the right track. The information about how to prevent cancer and other chronic illness already exists. It’s just a matter of applying it.

Source: Why Cancer Needs To Be Treated as a Metabolic Disease. Here is the link https://articles.mercola.com/sites/articles/archive/2019/01/06/metabolic-disease.aspx

I invite you to Follow my Blog, Facebook or be added to my email distribution list. My focus is to maximize my physical performance and mental clarity, body composition, and most importantly overall health with a wholesome diet and exercise.

I will bring you compelling articles on Ketogenic and GAPS diets, the Super Slow High-Intensity Exercise Program and supplements.

To follow my Blog, please click the Follow button to receive an email when the next posting is available. Hint: You may have to click the Accept and Close button before follow is available.

I thrive on feedback. Please let me know you are interested in the content by clicking Like, Commenting or sending me a message or email about the Post.

If you wish to contact me by Email, please email lpolstra@bell.net using this form.

May you Live Long Healthy.

Yours truly,

Lydia Polstra

Email: lpolstra@bell.net

Facebook: https://www.facebook.com/2healthyhabits/

Blog: https://2healthyhabits.wordpress.com

Disclaimer: The content of this email or Post is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.

Never Fear Cancer

Raymond Francis tells us how to Never Fear Cancer in his video. This is the transcript.

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Hey everybody, this is scientist Raymond Francis. You know my mission is to help people like you get well and stay well.

Let’s talk about cancer. Cancer is a most feared disease because our doctors are clueless on how to cure it. After heart disease, cancer is the leading cause of death. It kills about 600,000 Americans every year. It’s outrageous that we allow this to happen.

About 90% of all cancers are caused by diet and lifestyle. Since diet and lifestyle are choices almost anybody can choose to prevent or reverse cancer.

You know if there is only two causes of disease: deficiency and toxicity. So to prevent or reverse any disease this is where the focus has to be.  Modern medicines focus on treating only the symptoms of disease with toxic drugs and surgery and chemotherapy and radiation is just badly misplaced and this is resulting in an epidemic of chronic disease and our high cancer death rate.

Conventional medicine offers only false hopes and high prices with it’s dangerous and ineffective treatments.

If you want to prevent or reverse cancer changing your diet detoxifying and supplementing are essential. So get all the bad foods out of your life. That is sugar, wheat, dairy, excess animal protein and all the processed oils and for that matter all the processed foods. Get them out of your life.Substitute fresh organic vegetables especially cruciferous vegetables (cauliflower, cabbage, garden cress, bok choy, broccoli, brussels sprouts and similar green leaf vegetables). Get exercise, sunlight, sauna regularly. Supplement with high-quality nutrients and these nutrients should include a good multivitamin, a vitamin C, vitamin D, essential fatty acids, selenium, glutathione, Co Q 10, curcumin, Quercetin (anti-inflammatory)and real olive oil.

Health is a personal responsibility and only you can prevent or reverse cancer.

Anyone wishing to accept this responsibility should read my book, Never Fear Cancer Again. High-quality nutritional supplements are essential since it’s no longer possible to get the nutrition you need even if you eat a good diet. The high quality brand I take is Beyond Health and if you want to learn more about how to prevent or reverse cancer get yourself a copy of Never Fear Cancer Again.   Thank you very much for listening. Have a super great day!

Here is the link to the book, Never Fear Cancer Again https://www.amazon.ca/Never-Fear-Cancer-Again-Prevent/dp/075731550X

The US link to the supplements is through Beyond Health https://beyondhealth.com/bh-supplements.html?limit=all

For Canadians, the same product is distributed under the name, Perque. Here is the link, hover over the Products menu for a list of supplements https://www.perque.com/products/

Raymond Francis, D.Sc., M.Sc., RNC has been called a “brilliant advanced thinker” and has been cited as “one of the few scientists who has achieved a breakthrough understanding of health and disease.”

Raymond is an internationally recognized leader in the field of optimal-health maintenance and a pioneer in transforming our failed disease-care system to a true health-care system.

He is a chemist by training, a graduate of M.I.T., a bestselling author, and a world-class speaker.

He has written five breakthrough books, the international bestseller Never Be Sick Again, Never Be Fat Again, Never Fear Cancer Again, Never Feel Old Again, and The Great American Health Hoax. Here is the link to The Great American Health Hoax.

Source: Never Fear Cancer https://www.youtube.com/watch?v=VuH5sVn7U1M

I invite you to Follow my Blog, Facebook or be added to my email distribution list. My focus is to maximize my physical performance and mental clarity, body composition, and most importantly overall health with a wholesome diet and exercise.

I will bring you compelling articles on Ketogenic and GAPS diets, the Super Slow High-Intensity Exercise Program and supplements.

To follow my Blog, please click the Follow button to receive an email when the next posting is available. Hint: You may have to click the Accept and Close button before follow is available.

I thrive on feedback. Please let me know you are interested in the content by clicking Like, Commenting or sending me a message or email about the Post.

May you Live Long Healthy.

Yours truly,

Lydia Polstra

Email: lpolstra@bell.net

Facebook: https://www.facebook.com/2healthyhabits/

Blog: https://2healthyhabits.wordpress.com

Disclaimer: The content of this email or Post is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.

Genes may load the gun, but environment pulls the trigger. – Pamela Peeke, M.D.,M.P.H

Epigentics

Dr. Raymond Francis says, there is an enormous amount of misunderstanding about genes. Our physicians blame everything on age. Wrong!  By themselves, genes do not determine our sickness or health. It’s the instructions the genes receive that are responsible for our health and performance.

I believe the best way to predict my future is to create it. I believe your health is not determined by your genetics. To do that, I make it a daily habit to find ways to keep healthy.

From Dr. Natasha McBride: Do you recommend genetic testing?

Dr. Natasha Campbell-McBride holds a degree in Medicine and Postgraduate degrees in both Neurology and Human Nutrition.  In her clinic in Cambridge she specializes in nutrition for children and adults with behavioral and learning disabilities, and adults with digestive and immune system disorders.

ANSWER: I would recommend that you look into the new science of epigenetics. The upshot of it is that our genetics DO NOT determine our destiny! We are all equipped with a huge choice of genes to use. Who chooses which genes to use on a daily basis? The environment, of which your diet is one of the most important factors. Depending on what you eat on a daily basis, what chemicals you are exposed to and other environmental factors, YOU CHOOSE which genes in your body you are going to express and which genes are going to stay dormant. So, whatever genetics you were born with are not important; it is the environmental factors that you choose for yourself that predetermine your health. The only exception to this rule is a small group of genetic diseases, such as Down’s syndrome.

SOURCEGAPSdiet.com FAQs Pg. 171: https://owndoc.com/pdf/GAPS-diet-scam.pdf

What follows is a summary of one of chapters of Dr. Raymond Francis’s book, The Great American Health Hoax.

  1. When it comes to disease, we control our genes: our genes do not control us. Most genes are DNA codes. They respond to instructions we give them. We instruct our genes through the cellular environments we create with our lifestyle choices.

All of us have genetic predisposition to certain ailments, but that doesn’t mean we will develop problems. In order to get the ailment, specific genes have to be activated and express in a certain way. So don’t activate them!

  1. A good diet, exercise, meditation, sunlight, fresh air, adequate sleep, systemic alkalinity, a normal sodium/potassium balance, limiting toxic exposures, detoxification, hormonal balance and a positive attitude create an optimal cellular environment for genetic expression. When you do this right, you will maintain normal chemistry in your cells. Normal chemistry gives genes healthy instructions, keeping disease turned off.
  1. Genes get damaged and repaired all the time. Ideally, repair keeps pace with damage. When it does not, mutations occur. Mutations introduce chaos into biological systems, leading to cancer and other types of disease. Another kind of damage, epigenetic change, alters gene function without altering the DNA code. These come from environmental chemicals and poor nutrition interacting with genes and interfering with their normal expression. Mutated genes and epigenetic changes can both be passed down through generations.
  1. Life in the twenty-first century is damaging our genes and creating mutations in unprecedented ways and at an alarming rate. You can stop much of this damage by avoiding toxins, as well as ionizing and nonionizing radiation wherever possible.
  1. Support DNA repair by optimizing your nutrient intake, especially vitamins B3, B6, and B12; folate; zinc; and L-carnrtine. Most Americans are deficient in one or more of these nutrients.Unless you supply the nutrients the body needs to make DNA repairs, the job will go undone and genetic mutations will result.

Raymond Francis, D.Sc., M.Sc., RNC hasbeen called a “brilliant advanced thinker” and has been cited as “one of the few scientists who has achieved a breakthrough understanding of health and disease.”

Raymond is an internationally recognized leader in the field of optimal-health maintenance and a pioneer in transforming our failed disease-care system to a true health-care system.

He is a chemist by training, a graduate of M.I.T., a bestselling author, and a world-class speaker.

He has written five breakthrough books, the international bestseller Never Be Sick Again, Never Be Fat Again, Never Fear Cancer Again, Never Feel Old Again, and The Great American Health Hoax. Here is the link to The Great American Health Hoax, you can read part of the book on line https://www.amazon.ca/Great-American-Health-Hoax-Disease-Free/dp/0757318495

I invite you to Follow my Blog, Facebook or be added to my email distribution list. My focus is to maximize my physical performance and mental clarity, body composition, and most importantly overall health with a wholesome diet and exercise. 

I will bring you compelling articles on Ketogenic and GAPS diets, the Super Slow High-Intensity Exercise Program and supplements.

To follow my Blog, please click the Follow button to receive an email when the next posting is available. Hint: You may have to click the Accept and Close button before follow is available.

I thrive on feedback. Please let me know you are interested in the content by clicking Like, Commenting or sending me a message or email about the Post.

If you wish to contact me by Email, please email lpolstra@bell.net using this form.

May you Live Long Healthy.

Yours truly,

Lydia Polstra

Email: lpolstra@bell.net

Facebook: https://www.facebook.com/2healthyhabits/

Blog: https://2healthyhabits.wordpress.com

Disclaimer: The content of this email or Post is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.

The Sad Saga of Saturated Fat

In the US and Canada dietary guidelines do not take into consideration the recent extensive scientific research into role of saturated fats.

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Two generations of researchers have tried to prove that eating saturated fat (such as beef, pork, dairy, eggs, chocolate, and tropical oils) causes heart disease. This hypothesis is false.For proof look to multiple recent meta-analyses of large populations followed carefully for decades, examining what they eat and what they die of.  All show no consistent association between dietary saturated fat intake and risk for heart disease or death from all causes.In fact some of these studies show just the opposite – they suggest that one’s risk for a coronary event increases when dietary saturated fat is reduced and replaced by carbohydrate.

By continuing to provoke fear about the harmful effects of saturated fat, the likely response is that people will seek out foods low in fat and higher in carbohydrate. In fact, according to a government-funded survey, Americans have decreased their consumption of saturated fat and replaced those calories with an even greater amount of carbohydrate. In the same time interval rates of obesity and diabetes have rocketed skywards.

Much of what we’ve been taught about dietary fat is wrong. How could this be – a good place to start would be to read Good Calories, Bad Caloriesby Gary Taubes andThe Big Fat Surpriseby Nina Teicholz, both highly regarded investigative journalists.

In short, 50 years ago diseased coronary arteries were found to contain buildups of cholesterol and saturated fat. Professor Ancel Keyes of the University of Minnesota hypothesizedthat too much of these two nutrients in the diet were the cause – i.e., his hypothesis was built on the flawed concept that you are what you eat. Then came well-done studies showing that blood levels of saturated fats predict future cases of heart disease and diabetes, thus appearing to support Keyes’ hypothesis. But this works only if you believe “you are what you eat”,a concept that doesn’t pass the common sense test.

Obviously, the key question here is, what’s the precise relationship between dietary saturated fat and blood levels of saturated fat?”The scientific evidence clearly shows that dietary saturated fat intake has little to do with saturated levels in our blood, then what does? There is, in fact, sound evidence that dietary carbohydrate is a major determinant of serum saturated fat levels.

 We know this because two respected research groups fed humans carefully measured, weight-maintaining diets either high in carbohydrate or moderate in carbohydrate. In both studies, blood levels of saturated fats went up dramatically on the high carb diets, even though they were very low in fat.

We (Virta) performed a weight loss study during which we fed diets varying from 32 up to 84 grams of saturated fat per day, with “healthy carbohydrate” making up the energy difference when dietary fat was reduced. In blood triglycerides and cholesteryl esters, saturated fat levels trended upwards when the high carbohydrate, very low fat diet was consumed, despite the diet being energy restricted, causing on-going body fat loss.

A high carbohydrate intake has two effects in the body that promote higher levels of saturated fat.

First, carbohydrates stimulate the body to make more insulin, which inhibits the oxidation of saturated fat. Thus, when insulin levels are high, saturated fat tends to be stored rather than burned as fuel.

Second, a high carbohydrate intake promotes the synthesis of saturated fat in the liver.

This is particularly problematic for individuals with insulin resistance, characterized as “carbohydrate intolerance” in our recent book, (Volek J, Phinney SD. The Art and Science of Low Carbohydrate Living. Beyond Obesity, May 2011.) Available through Amazonhttps://www.amazon.com/Art-Science-Low-Carbohydrate-Living/dp/0983490708

Insulin resistance makes it harder for muscles to take up and use blood sugar, thus causing a higher propensity for the liver to convert dietary carbohydrate into body fat.

This combination of decreased oxidation and increased synthesis of saturated fat therefore results in accumulation of saturated fats in the blood and tissues.The culprit then is clearly not dietary saturated fat, but rather consumption of more carbohydrate than an individual’s body can efficiently manage.This threshold of carbohydrate tolerance varies from person to person, and it can also change over a lifetime.

In addition to the studies mentioned above in which high carbohydrate feeding increased blood levels of saturated fats, we conducted a pair of studies allowing 6-12 weeks for adaptation to moderate carbohydrate or very low carbohydrate diets. Because these were not very low-calorie diets, the low-carb diets were naturally pretty high in fat, containing 2-3 fold greater intakes of saturated fat than the moderate carbohydrate diets used as controls.

The results were pretty striking: compared to low-fat diets, blood levels of saturated fat were markedly decreased in response to the low carbohydrate, high fat diets.Our data indicates that this occurred because the low insulin levels accelerated the oxidation of all fats (and particularly saturated fat); plus the relative few dietary carbohydrates meant there wasn’t much of it to be converted into saturated fats. Thus, from the body’s perspective, a low-carbohydrate diet reduces blood saturated fat levels irrespective of dietary saturated fat intake.

There is convincing evidence that dietary carbohydrate exerts an important influence on how the body processes saturated fat. Thus, saturated fat, whether made in the body or eaten in the diet, is more likely to accumulate when aided and abetted by high levels of dietary carbohydrate, particularly in insulin-resistant individuals (as in type 2 diabetes or metabolic syndrome*).

* Metabolic syndrome is a clustering of at least three of the five following medical conditions: central obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein. Metabolic syndrome is associated with the risk of developing cardiovascular disease and type 2 diabetes. Source: https://en.wikipedia.org/wiki/Metabolic_syndrome

A one-size-fits-all recommendation to aggressively lower saturated fat intake with the expectation of lowering blood saturated fat levels is intellectually invalid and likely to backfire.

SOURCE: The Sad Saga of Saturated Fat by Jeff Volek, PhD, RD and Stephen Phinney, MD, PhD https://blog.virtahealth.com/the-sad-saga-of-saturated-fat/?fbclid=IwAR28z406CUcbrwZ-kdEWAoko7-gOMgPNJ4fgxy0HSeLkdLfZW1co244xP3cIn Categories: Science & Research. Please see the extensive list of studies under References.

I invite you to Follow my Blog, Facebook or be added to my email distribution list. My focus is to maximize my physical performance and mental clarity, body composition, and most importantly overall health with a wholesome diet and exercise.

 I will bring you compelling articles on Ketogenic and GAPS diets, the Super Slow High-Intensity Exercise Program and supplements.

 To follow my Blog, please click the Follow button to receive an email when the next posting is available. Hint: You may have to click the Accept and Close button before follow is available.

I thrive on feedback. Please let me know you are interested in the content by clicking Like, Commenting or sending me a message or email about the Post.

If you wish to contact me by Email, please email lpolstra@bell.net using this form.

May you Live Long Healthy.

Yours truly,

Lydia Polstra

Email: lpolstra@bell.net

Facebook: https://www.facebook.com/2healthyhabits/

Blog: https://2healthyhabits.wordpress.com

Disclaimer: The content of this email or Post is not intended for the treatment or prevention of disease, nor as a substitute for medical treatment, nor as an alternative to medical advice. Use of recommendations is at the choice and risk of the reader.